Hyocholic acid

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Hyocholic Acid 是一种最早在猪体内发现的胆汁酸。Hyocholic Acid 也可以在胆汁淤积患者的尿液样本中发现。Hyocholic Acid 通过激活 TGR5 和抑制 FXR 促进肠内分泌细胞 GLP-1 分泌。Hyocholic Acid 可抵抗 2 型糖尿病。

Hyocholic Acid is a bile acid found in pig. Hyocholic Acid can also be found in urine samples from patients with cholestasis. Hyocholic Acid promotes GLP-1 secretion via activating TGR5 and inhibiting FXR in enteroendocrine cells. Hyocholic Acid is known for its exceptional resistance to type 2 diabetes .

HCA (25 and 50 μM, 24 h) upregulates GLP-1 protein secretion in STC-1 and NCI-H716 cells.HCA (25 and 50 μM, 24 h) upregulates proglucagon gene transcription in STC-1 and NCI-H716 cells.Western Blot Analysis Cell Line:NCI-H716 cells Concentration:50 μM Incubation Time:48 h Result:Inhibited the high expression of SHP (small heterodimer partner) induced by the FXR agonist.

Hyocholic Acid (20 mg/kg, p.o.) suppresses BA depletion-induced blood glucose increase in pigs.Hyocholic Acid (100 mg/kg/day, p.o.) improves serum fasting GLP-1 secretion and glucose homeostasis in diabetic mouse models.Animal Model:BA depletion pigs Dosage:20 mg/kg Administration:Oral administration (p.o.) Result:Attenuated the increased blood glucose levels corresponding with GLP-1 decrease.Animal Model:db/db model, and the high-fat diet and streptozotocin (HFD+STZ) induced diabetic model Dosage:100 mg/kg/day Administration:Oral administration (p.o.) Result:Improved oral glucose tolerances shown by lower glucose levels.Increased circulating active GLP-1 levels and fasting insulin levels.

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547-75-1

408.57

C24H40O5

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 62.5 mg/mL (152.97 mM; 超声助溶 (<60°C)

[H][C@@]1(CC[C@@]2([H])[C@]3([H])[C@H](O)[C@H](O)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCC(O)=O

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(-20℃)

With Ice Pack

≥ 2 years